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LOT: LAB-23-50818-B
MOTS-c
MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a 16-amino acid mitochondria-derived peptide encoded by mitochondrial DNA, representing a novel class of intracellular signaling molecules. It activates the AMPK pathway and regulates the folate cycle and de novo purine synthesis under metabolic stress. During cellular stress, MOTS-c translocates to the nucleus and directs nuclear gene expression to restore metabolic homeostasis. Research has demonstrated its roles in improving insulin sensitivity, enhancing glucose uptake, reducing oxidative stress, improving mitochondrial bioenergetics, and modulating inflammation in aging, cardiovascular, metabolic, and orthopedic disease models.
Research Benefits
- Activates AMPK pathway and enhances glucose uptake in cellular models, supporting metabolic efficiency and insulin sensitivity in research
- Reduces mitochondrial reactive oxygen species emission and oxidative stress, improving intrinsic mitochondrial bioenergetic health
- Translocates to the nucleus under metabolic stress to regulate gene expression and restore metabolic homeostasis across multiple tissue types
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Total Price$104.68
MOTS-c is a mitochondria-derived peptide encoded by the 12S rRNA region of the mitochondrial genome, representing a recently discovered class of mitochondrial-encoded signaling molecules. It was first identified by researchers at the University of Southern California in 2015 during investigations of mitochondrial ORFs. Since its discovery, MOTS-c has been studied in controlled experimental settings for its potential influence on AMPK activation, metabolic stress adaptation, glucose regulation, and cellular energy homeostasis.