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TB-500
LOT: PEP-23-13054-B

TB-500

TB-500 is a synthetic peptide fragment derived from thymosin beta-4 (Tβ4), an actin-sequestering protein widely distributed across human tissues. Its sequence, Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Lys-Thr-Glu-Thr-Lys-Asn-Pro-Lys-Asp-Lys-Arg-Ala-Asp-Glu-Ile-Asn-Glu-Lys, binds to G-actin and modulates cell motility and structural organization. Research has demonstrated its ability to promote new blood vessel formation, reduce inflammatory signaling, and enhance cell migration essential for tissue repair across multiple tissue types. Phase 1 human safety studies have established tolerability, and preclinical models consistently show regenerative activity in musculoskeletal, cardiac, corneal, and wound healing applications.

Research Benefits

  • Binds to G-actin to regulate cell migration and structural organization, supporting tissue repair processes in experimental models
  • Promotes angiogenesis and new blood vessel formation across multiple tissue types in preclinical research settings
  • Reduces inflammatory signaling and supports extracellular matrix remodeling, enhancing systemic recovery in injury models

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Total Price$162.68
TB-500 is a synthetic peptide fragment corresponding to an active region of thymosin beta-4, a naturally occurring actin-sequestering protein present throughout the human body. Thymosin beta-4 was first identified in thymic tissue in the 1960s as a component of the thymosin fraction. Since its characterization, the active TB-500 fragment has been studied in controlled experimental settings for its potential influence on actin dynamics, cellular migration, vascular remodeling, and tissue regeneration processes.