NAD+
Nicotinamide Adenine Dinucleotide (NAD+) is a fundamental coenzyme present in every living cell, functioning as a redox cofactor in mitochondrial metabolism and as a substrate for key longevity enzymes including sirtuins and PARPs. Research has consistently shown that NAD+ levels decline with age, impairing mitochondrial function and compromising cellular repair mechanisms. Studies in animal models from yeast to mice have demonstrated lifespan and healthspan extension via NAD+ precursors. In humans, early trials show meaningful increases in NAD+ bioavailability and metabolic improvements. Its roles in the NAD+/NADH cycle, SIRT1/SIRT3 pathway activation, and PARP-mediated DNA repair make it a cornerstone of aging and regenerative biology research.
Research Benefits
- Supports mitochondrial ATP production and cellular energy metabolism via the NAD+/NADH redox cycle
- Activates sirtuin (SIRT1, SIRT3) and PARP pathways associated with DNA repair and stress resistance
- Influences longevity-related molecular signaling, with demonstrated healthspan extension in preclinical models